One may ask why there is a controversy about a vaccine that has the potential to reduce the incidence of the second most common cause of cancer death in women worldwide (cervical cancer). Dr Krishnan addresses this question from the standpoint of the knowledge of the safety and efficacy of this vaccine and the public’s acceptance of the vaccine in 2008, 2 years after its approval by the US Food and Drug Administration (FDA)…Dr Krishnan does an outstanding job of explaining the HPV vaccine … Furthermore, she provides a superb discussion on counseling patients with HPV infections…This discussion can be a useful guide for the clinician who deals with patients with any STD…In summary, The HPV Vaccine Controversy  is a useful guide for the clinician and for the lay public 4 years after FDA approval of the quadrivalent HPV vaccine… http://www.eblue.org/article/S0190-9622(10)00506-2/fulltext